Inputs of mercury to many ecosystems are largely derived from atmospheric deposition associated with a combination of direct atmospheric emissions and secondary re-emission from historical releases.  Inputs of mercury can be methylated and subsequently bioaccumulate and biomagnify along terrestrial and aquatic food chains, resulting in elevated exposure to humans and animals. Despite concerns over health effects of mercury exposure, we have a limited understanding of large-scale temporal and spatial patterns of the interrelations of mercury emissions, transport, and fate. In this presentation we summarize: (i) temporal trends and spatial patterns of mercury emissions, (ii) atmospheric concentrations of mercury species and wet mercury deposition, and (iii) spatial patterns of soil mercury in the conterminous U.S. Observations of atmospheric chemistry were obtained from the Atmospheric Mercury Network (AMNet) and wet deposition data were obtained from the Mercury Deposition Network (MDN) of the National Atmospheric Deposition Program. Soil data from the upper 5 cm and A and C horizons were obtained from a USGS survey of 4,814 sites. Consistent with recent decreases in mercury emissions, this analysis shows significant decreases in concentrations of gaseous elemental mercury and gaseous oxidized mercury at a majority of AMNet sites, which are largely located in the eastern U.S. The majority of MDN sites with significant trends in the eastern U.S. exhibited decreases in annual volume-weighted concentrations of mercury, while few significant trends were evident in the West. There were far fewer significant changes in wet mercury deposition due to variability in precipitation quantity, though many eastern sites exhibited a decreasing pattern. Soil mercury concentrations were generally similar between the surface and A horizons, but much lower in the C horizons. Concentrations of surface soil mercury were generally highest in the East, coinciding with higher concentrations of soil organic matter and an abundance of forest cover, and generally lower in the West except for elevated concentrations in lands adjacent to the Pacific coast. Forested lands generally exhibited the highest mercury concentrations in surface soils, followed by developed lands, planted/cultivated lands, herbaceous uplands, shrublands, and barren lands. Although elevated surface soil mercury in the eastern U.S. was coincident with major mercury emission sources, concentrations were only weakly correlated with estimates of wet plus dry mercury deposition.