Ecological research is increasingly embracing the concept of the ‘macrosystem’: a collection of ecological systems interacting over large temporal and spatial scales. Macrosystem research requires comprehensive datasets covering broad geographic areas and preferably long timescales. The National Ecological Observatory Network (NEON) represents a concerted effort to collect a robust and diverse suite of ecological data from 81 sites across the United States over 30 years. Included in the NEON design is the collection and dissemination of wet deposition chemistry from 41 NEON sites (37 terrestrial and 7 aquatic). Thirteen NEON wet deposition collects are co-located (five less than 0.5 km) with existing NADP sites. NEON analyzes for a nearly identical suite of chemistry as NADP (major ion concentrations, pH, and conductivity), but there is some potentially important variation in collection methods with respect to sampling frequency and the collector used. Here we present plans for a preliminary study using co-located NEON and NADP sites to assess the interoperability of wet deposition data from the two networks.